Amphotericin B

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Amphotericin B Specification

Molecular Weight
924.1 g/mol

Smell
Characteristic odor

Poisonous
No considered safe in prescribed doses

Structural Formula
Complex polyene macrolide structure

EINECS No
215-742-2

Taste
Bitter

Shelf Life
2 years if stored properly

Melting Point
170-175C (decomposes)

Particle Size
Micro-fine powder

Color
Yellow to orange

Storage
Store at 2-8C protected from light

Solubility
Slightly soluble in water soluble in methanol and DMSO

Heavy Metal (%)
0.001%

Loss on Drying
5%

Ph Level
5.5-7.5 (aqueous solution)

Molecular Formula
C47H73NO17

HS Code
294200

Medicine Name
Amphotericin B

Chemical Name
Amphotericin B

CAS No
1397-89-3

Type
Antifungal

Grade
Pharmaceutical Grade

Usage
Used to treat fungal infections

Purity(%)
98%

Appearance
Yellow or orange powder

Physical Form
Powder

About Amphotericin B

Specification:

Name: Amphotericin B
CAS No.:1397-89-3
Formula:C47H73NO17
Molecular Weight:924.21
Deleted CAS: 1407-52-9|170451-87-0|30782-62-8|54482-28-9|8055-20-7

Synonyms:

Fungizone;Amphozone;component of Mysteclin-F;Mysteclin-F;33-((3-amino-3,6-dideoxyhexopyranosyl)oxy)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid;Amphocin;IAB;Amphotericin B (JP14/USP);Amphotericin B (U.S. FDA Approved);AmphotericcinB;

EINECS:215-742-2
Density:1.34 g/cm3
Melting Point:>170 °C
Boiling Point:1140.4 °C at 760 mmHg
Flash Point:643.5 °C
Solubility: <0.1 g/100 mL at 21 °C in water
Appearance: crystalline yellow solid

Broad-Spectrum Antifungal Treatment

Amphotericin B is classified as a polyene macrolide antibiotic, widely recognized for its effectiveness against a variety of systemic fungal infections. It is often prescribed when other antifungal medications are ineffective, making it an essential option in critical therapeutic settings.

High Stability and Purity

This product is supplied as a micro-fine powder with a yellow to orange hue and a distinctive odor. Its high stability and purity (98%) ensure that patients and medical professionals receive a consistent and reliable formulation, backed by strict pharmaceutical standards.

Safe Storage and Handling

To maintain Amphotericin Bs efficacy, it should be stored at 28C, protected from direct light. Proper storage conditions ensure a shelf life of up to two years, preserving the powders quality and therapeutic potential for medical use.

FAQs of Amphotericin B:

Q: How should Amphotericin B be stored to ensure maximum shelf life?

A: Amphotericin B should be stored at a temperature between 28C and protected from light. Under these conditions, the powder maintains its stability and potency for up to two years.

Q: What is Amphotericin B primarily used for?

A: Amphotericin B is used to treat a wide range of serious fungal infections, especially in cases where first-line antifungal medications are not effective.

Q: When is Amphotericin B typically administered in the treatment process?

A: It is typically administered when fungal infections are severe or resistant to other antifungals. The timing and dosage depend on the infections severity and the patients health status.

Q: What are the advantages of using pharmaceutical-grade Amphotericin B?

A: Pharmaceutical-grade Amphotericin B offers high purity (98%) and low heavy metal content (0.001%), ensuring safety and consistent therapeutic performance for medical treatments.

Q: Where is this Amphotericin B supplied from?

A: This Amphotericin B is manufactured, exported, and supplied from India, complying with international quality standards for pharmaceutical products.

Q: How is Amphotericin B typically dissolved for use?

A: Amphotericin B is slightly soluble in water but dissolves more efficiently in solvents such as methanol and DMSO, allowing for precise preparation in laboratory and clinical settings.

Q: What are the benefits of its micro-fine powder form?

A: The micro-fine powder form ensures easier dissolution, accurate dosage, and efficient delivery during pharmaceutical compounding, enhancing its effectiveness in treatment.

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