Calcipotriol Monohydrate

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Calcipotriol Monohydrate Specification

Poisonous
NO

Structural Formula
C27H44O4

Smell
Odorless

Molecular Formula
C27H40O3H2O

Solubility
Insoluble in water; soluble in ethanol and organic solvents

Loss on Drying
0.5%

Shelf Life
2 years

EINECS No
604-581-3

Storage
Store in a cool dry place away from light and moisture

Particle Size
Micronized

HS Code
29372290

Color
White to off-white

Molecular Weight
430.64 g/mol

Heavy Metal (%)
10 ppm

Melting Point
138-140C

Medicine Name
Calcipotriol Monohydrate

Chemical Name
Calcipotriol monohydrate

CAS No
147657-22-5

Type
Active Pharmaceutical Ingredient (API)

Grade
Pharmaceutical Grade

Usage
Used for the treatment of psoriasis

Purity(%)
99%

Appearance
White to off-white crystalline powder

Physical Form
Solid

About Calcipotriol Monohydrate

Product Details:

Packaging Size 25 kg

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3).Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response.Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Specification:

Formal Name: 24-cyclopropyl-(1,3,5Z,7E,22E,24S)-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, monohydrate
CAS Number :112828-00-9
Synonyms : Calcipotriene
Molecular Formula : C27H40O3 H2O
Formula Weight :412.6
Purity: 98%
Formulation A crystalline solid
Product Type: API

High Purity for Superior Clinical Outcomes

Calcipotriol Monohydrate boasts a pharmaceutical-grade purity of 99%, ensuring that each batch delivers reliable results for psoriasis treatment. The micronized particle size enhances absorption and consistency in pharmaceutical formulations, thus promoting effective topical applications.

Optimal Storage and Handling

To maintain potency, Calcipotriol Monohydrate should be stored in a cool, dry place away from light and moisture. This helps prevent degradation and ensures the APIs stability throughout its two-year shelf life, making it suitable for manufacturers and suppliers globally.

Safe and Efficient Formulation

With a loss on drying of 0.5% and heavy metal content not exceeding 10 ppm, Calcipotriol Monohydrate meets stringent pharmaceutical standards. It is odorless and non-poisonous, facilitating safe handling during formulation processes and guaranteeing quality output for dermatological therapies.

FAQs of Calcipotriol Monohydrate:

Q: How is Calcipotriol Monohydrate used in pharmaceutical products?

A: Calcipotriol Monohydrate serves as an active pharmaceutical ingredient primarily formulated into topical medications for the treatment of psoriasis. It is incorporated into creams, ointments, and solutions to help regulate skin cell production and alleviate symptoms.

Q: What benefits does Calcipotriol Monohydrate offer compared to other APIs?

A: Its high purity (99%) and micronized particle size ensure consistent efficacy and absorption. Additionally, it is odorless, non-poisonous, and complies with strict pharmaceutical regulations, making it a safe and effective option for topical therapies.

Q: When should Calcipotriol Monohydrate be stored and handled with special care?

A: During both storage and handling, Calcipotriol Monohydrate should be kept in a cool, dry environment and protected from light and moisture. These precautions ensure the stability and effectiveness of this pharmaceutical grade API throughout its shelf life.

Q: Where is Calcipotriol Monohydrate manufactured and exported from?

A: This API is manufactured, supplied, and exported by pharmaceutical companies based in India, adhering to international standards for purity and safety.

Q: What is the process of formulating Calcipotriol Monohydrate for topical use?

A: Calcipotriol Monohydrate is blended with suitable carriers, solvents, and stabilizers to create creams or ointments. Its micronized form allows for uniform distribution, while its solubility in ethanol and organic solvents aids in formulation.

Q: What is the main usage of Calcipotriol Monohydrate in dermatology?

A: Its primary use is in the management of psoriasis, where it helps normalize skin cell turnover, reducing scaling and inflammation associated with the condition.

Q: Is Calcipotriol Monohydrate safe for pharmaceutical applications?

A: Yes, it is considered safe when used as directed, with low loss on drying, minimal heavy metal content, and no poisonous components. Proper formulation and handling are crucial for optimal safety and efficacy.

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