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Modafinil, sold under the brand name Provigil and Modalert among others,is a medication to treat sleepiness due to narcolepsy, shift work sleepdisorder, or obstructive sleep apnea (OSA). In OSA continuous positive airwaypressure is the preferred treatment. Â While it has seen off-label use as a purportedcognitive enhancer, evidence for any benefit is lacking. Â It is taken by mouth.
Common side effects include headache, anxiety, troublesleeping, and nausea. Serious side effects may include allergic reactions suchas anaphylaxis, StevensÃÂÃÂ¢Ã¢ÂÂ¬Ã¢ÂÂJohnson syndrome, abuse, or hallucinations. It isunclear if use during pregnancy is safe. Â The amount of medication used may need to beadjusted in those with kidney or liver problems. Â It is not recommended in those with anarrhythmia, significant hypertension, or left ventricular hypertrophy. How itworks is not entirely clear. One possibility is that it may affect the areas ofthe brain involved with the sleep cycle.